Amos Scientific PTY. LTD.
Amos Scientific PTY. LTD.

Precautions of Using A Cryostat during Trimming, Sectioning, and Mounting

Nov 02 , 2023

Introduction to Cryostat Microtomes and their Importance

The cryostat microtome is an essential piece of equipment used in laboratory settings for the preparation and analysis of tissue samples. Manufactured by Amos Scientific, this cutting-edge device is designed to operate at extremely low temperatures, enabling researchers to obtain thin and precise sections. In this blog, we will explore the precautions that need to be taken while using a cryostat microtome, its significance in scientific research, and how its price varies across different models.

Understanding Cryostat Microtome Functionality and Applications

A cryostat microtome combines freezing and cutting technology to allow researchers to obtain tissue sections efficiently. It works by rapidly freezing the tissue sample and mounting it onto a specimen holder, facilitating precise sectioning. This process is critical for various studies, such as histology, immunohistochemistry, and molecular biology. The cryostat microtome's versatility makes it an indispensable tool for researchers in fields like medicine, pathology, and biomedical research.

The Importance of Following Precautions

Utilizing a cryostat microtome requires precision and adherence to safety precautions to ensure accurate results and protect researchers from potential hazards. Here are some key precautions to consider:

1. Personal Protective Equipment (PPE): Always wear appropriate PPE, including gloves, lab coats, and safety glasses while operating the cryostat microtome. PPE protects against potential exposure to hazardous substances and reduces the risk of injuries caused by sharp instruments.

2. Regular Maintenance: Regularly maintain and clean the cryostat microtome to ensure optimal performance. Lubricate moving parts, disinfect work areas, and periodically check the settings for accuracy and stability. Following manufacturer guidelines is crucial for safe and effective use.

3. Temperature Control: Maintain stable and appropriate temperatures within the cryostat microtome to prevent thermal damage to the delicate tissue samples. Monitor the temperature using the built-in thermometer and adjust settings accordingly to prevent freezing artifacts and maintain tissue integrity.

Choosing the Right Cryostat Microtome and Understanding Price Variation

When selecting a cryostat microtome, it's essential to consider your specific research requirements, laboratory budget, and the reputation of the manufacturer. Amos Scientific is a reputable cryostat manufacturer known for producing high-quality instruments. The price of a cryostat microtome can vary depending on various factors such as model specifications, additional features, and advanced functionalities. It is crucial to evaluate these factors in relation to your research needs and available budget.


In conclusion, the cryostat microtome is an invaluable tool in modern scientific research laboratories. It enables researchers to obtain precise tissue sections, facilitating various studies and diagnostic procedures. However, it is important to handle the cryostat microtome with care and follow necessary precautions to ensure both accurate results and personal safety. Moreover, by choosing a reputable manufacturer like Amos Scientific and considering the price variations based on model specifications, researchers can make informed purchasing decisions.

Remember, safety should always be a top priority, and maintaining the functionality of the cryostat microtome through regular maintenance is crucial for achieving consistent and reliable outcomes in scientific research.

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